Furcifer antimena can be found in southwest Madagascar,[2] more specifically between 5 and 80 metres (16 and 262 feet) above sea level mainly around Antsokay, Toliara and Ankotapiky.

[1] Furcifer antimena was ranked as a Vulnerable species by the International Union for Conservation of Nature (IUCN) because it is found in an area where there is massive clearing of the forest for agriculture and charcoal production and because the population is believed to be declining.

[1] Furcifer antimena males have a dorsal crest[3] formed of about thirty cone-shaped scales, each of which is between 3 and 6 millimetres (0.12 and 0.24 inches) in length.

[4][3] Furcifer antimena typically lives among thorny scrub in dry savannah locations.

The female lays a clutch of between ten and fifteen eggs in a concealed position, burying them in sandy soil.