Departments at the school include English; mathematics; physical, earth, and life sciences; social studies; physical education; vocal and instrumental music; video, photographic, sculpted, painted and drawn arts; foreign languages; health and sports medicine; auto and wood shop; and engineering.

In 2010, Antioch High started the Academy of Engineering and Designing a Greener Environment (EDGE) which is a pathway that integrates the core classes with an engineering class to give students a peek into careers in engineering.

Professor Jason Ebner from UC Berkeley gives instruction at this institution.

In 2012, Antioch launched an Environmental Studies Academy.

In 2012, Antioch launched a Leadership and Public Service Academy.