Antofagasta de la Sierra is the northernmost department of Catamarca Province in Argentina.

The provincial subdivision has a population of about 1,300 inhabitants in an area of 28,097 km2 (10,848 sq mi), and its capital city is Antofagasta de la Sierra.

There are over 200 volcanos situated in the Antofagasta de la Sierra volcanic field, the most notable of them being Antofalla, Carachi Pampa, Alumbrera and Galán.

There is evidence of hunter-gatherer people in the region dating back about 8,000 years.

This article about a place in Catamarca Province, Argentina is a stub.