Born in Douai, Spanish Netherlands, he was attached at an early age to the English community of St. Bonaventure's convent there, and became a Franciscan Recollect friar, and taught philosophy and divinity.

[1] Towards the close of his life he engaged in sharp controversies on metaphysical topics with John Sergeant, a secular priest.

At the twenty-third chapter of his order, assembled in London on 9 July 1693, he was elected provincial, and he held that office till his death on 9 August 1699.

[3][4] Le Grand authored An Entire Body of Philosophy in 1694 which reduced Cartesianism to a "scholastic" scheme.

He is noted for the effort he made to render the approach of Descartes more apparently scholastic, to improve its reception with traditionalists.