He was therefore the uncle of Anne de Pisseleu d'Heilly, mistress of François I, to whom he owed his ecclesiastical career; there is no record of his having taken holy orders.

[4] Shortly thereafter he was named Master of the Royal Chapel (Maître de l'Oratoire[5]) of Francis I, a post he held until his promotion to Grand Almoner in 1543.

He was assigned the Deaconry of Santa Maria in Portico on 15 July 1541, which was temporarily (pro hac vice) promoted to the rank of titular church.

His red hat was sent to him in France, and was presented to him by the Papal Legate, Cardinal Alessandro Farnese in a ceremony held in Notre Dame de Paris on Pentecost, 1540.

[9] In 1544 Cardinal Sanguin's niece's brother,[10] Charles Pisseleu, who had been Administrator of the diocese of Mende since 1538, was made Bishop of Condom, thanks to the patronage of King Francis' sister, Marguerite of Navarre.

Finally on February 7, 1550, in the evening, Cardinal Giovanni Maria Ciocchi del Monte was elected Pope Julius III.