Antoinette Smythe Garnes (about 1887 – July 2, 1938) was an American soprano singer active in the 1920s.

She studied at Detroit Central High School, Detroit Conservatory of Music, Howard University, and Chicago Musical College; at the last institution she studied with Edoardo Sacerdote,[1] earned a bachelor of music degree in 1919,[2] and was the college's first black winner of the Alexander Revell diamond medal.

[5] In 1923 Garnes was the only African American member of the Chicago Grand Opera Company.

[3] Music critic Agnes Beldon noted Garnes's "sterling vocal ability and fine training".

[9] Her solo recitals were sponsored by local black women's clubs, and benefited charities such as the Phyllis Wheatley Orphan's Home in Wichita.