His four older brothers were all painters, the best-known of them being Johann Heinrich Tischbein.
In 1753, he enrolled at the Royal Academy of Art in The Hague, which had an international reputation for its teaching in the Baroque style.
In 1758, he entered the service of Count Christian August von Solms-Laubach as his secretary.
He moved to Hanau in 1769 to become court painter for William I, Elector of Hesse and, after 1772, worked to establish an art academy there and became a teacher.
He worked not only for the nobility, but also for wealthy aristocrats, including Johann Christian Senckenberg, the Brentanos and the La Roches.