Zeiss was chief consultant for mental health services at the Central Office of the United States Department of Veterans Affairs – the first woman and the first psychologist and nonphysician to hold this position.
"[4] Her advice to women in leaderships includes being nice, being responsible, staying involved, having vision, and growing things.
[10] Her research career focused on cognitive behavioral therapy in the treatment of depression,[11] and mental health and sexuality in later life.
[12] Zeiss is active in the Women in Leadership Special Interest Group of the Association of VA Psychology Leaders.
In 2010 the Association of VA Psychology Leaders established the Antonette Zeiss Distinguished Leadership Award to honor VA psychologists who have shown expert leadership during their career and a strong commitment to the work of providing health care for Veterans.