Her father arranged for her to marry a cousin, but he was uninterested in the family business and wasted a large part of her fortune.
The marriage produced two children: a daughter, Maria de Assunção, later known as the Countess of Azambuja, and one son, António Bernardo Ferreira.
Ferreira received her nickname, Ferreirinha (an affectionate diminutive of her name in Portuguese), for her devotion and care for the working families who farmed her lands and vineyards.
She was supported in her business efforts by her administrator José da Silva Torres, who eventually became her second husband.
She is considered one of the leaders in the history of the Douro valley and an influence in to the continued popularity and success of Portuguese wines, surviving through the phylloxera blight of the late 19th century.