[7][8][9] In the 4 × 100 m medley relay, Machaira, along with Katerina Klepkou, Aikaterini Sarakatsani, and Marina Karystinou, finished twenty-second from the prelims in a final time of 4:24.80.

[10][11] At the 2000 Summer Olympics in Sydney, Machaira drastically shortened her program, swimming only in the 100 m freestyle.

[12][13] She challenged seven other swimmers in heat five, including U.S. legend and top favorite Dara Torres.

With one swimmer scratching out of the race in her heat, Machaira edged out Austria's Judith Draxler on the final lap to pick up a sixth seed by 16-hundredths of a second in 57.24.

[14][15] At the 2001 Mediterranean Games in Tunis, Tunisia, Machaira helped the Greeks captured a silver medal in the 4 × 100 m freestyle relay with a sterling time of 3:48.74.