Antonio Saverio De Luca (28 October 1805 – 28 December 1883) was an Italian bishop and prefect of the Pontifical Congregation for Studies as well as Cardinal-Priest of San Lorenzo in Damaso and Cardinal-Bishop of Palestrina.

Born Bronte, Sicily, he was ordained on 10 February 1839, aged 33, as Priest of Monreale, Italy.

On 22 December 1853, aged 48, he was appointed as Titular Archbishop of Tarsus.

On 16 March 1863, aged 57, he was appointed Cardinal-Priest of Santi Quattro Coronati and elevated to the Cardinalate.

On 15 July 1878, he was promoted Cardinal-Bishop of Palestrina by Pope Leo XIII He was named Vice-Chancellor of the Holy Roman Church on the same day, and was granted the titular church of S. Lorenzo in Damaso held in commendam (under administration), a church to which a Vice-Chancellor was usually assigned.