Asprucci was a pupil of Nicola Salvi, the creator of the Trevi Fountain, whom he assisted with creating various works.

[1] Once independent, he worked for the Duke of Bracciano and built a house for Marcantonio Borghese IV in Pratica di Mare.

[2] His most famous work is the small temple dedicated to Aesculapius inside the gardens of Villa Borghese.

This small neoclassical building with a tetrastyle ionic portico is located in the middle of the Roman villa's pond.

[2] Asprucci's son, Mario, was commissioned to design the classical villa Ickworth House in the Suffolk countryside in 1795.