He was a son of Francesco, Lord of Sykaminon, and Margareta Malpigli.

Antonio II grew up in Florence until 1413, when his father's cousin Antonio I (son of Nerio I) called him and his brother Nerio II to Greece to live at his court.

When the elder Antonio died in January 1435, he left the duchy to Nerio II under the regency of his widow Maria Melissene.

[1] Antonio ruled energetically but briefly and died in 1445, to be replaced by his deposed brother.

He married Maria Zorzi and had a child: This biographical article of a European noble is a stub.