[2] In the field of atherosclerosis, his basic science research interests include clinical disorders of lipid transport and the structure, metabolism, and function of lipoproteins and apolipoproteins.
He and his associates were the first to achieve complete synthesis of a plasma apolipoprotein (apo C-I); they also determined the complete cDNA and amino acid sequence of apo B-100, one of the largest proteins ever sequenced and a key protein in atherosclerosis.
Gotto has played a leading role in several landmark clinical trials demonstrating that cholesterol-lowering drug treatment can reduce the risk for heart disease.
He is a member of the Institute of Medicine and the American Academy of Arts and Sciences and a recipient of many honors.
Gotto has been on the editorial boards of numerous academic publications, including a senior editor of The Medical Roundtable, Cardiovascular Edition, a peer-reviewed journal publishing expert roundtable discussions on compelling topics.