Born at Portogruaro, he studied law at the University of Padua, and worked in the papal administration.
This caused a crisis with the other Friulian nobles, after which Panciera followed a pro-Venetian policy, leading the people of Cividale del Friuli to ask his removal to Pope Gregory XII.
On 13 June 1408 he was therefore replaced as patriarch by Antonio di Ponte, but, with the support of some cardinals who opposed Gregory, he obtained his reinstatement at the Council of Basel.
In 1411 he was elected cardinal by John XXIII in order to free the Aquileian throne to Louis of Teck, a nobleman whose German allegiances were useful for the antipope.
In 1417 he participated in the election of Pope Martin V, who made him administrator of Satriano and then of Frascati (1420).