He was born in St. Petersburg, Russian Empire where he began his musical studies with his father who was also called Antonio.
(Antonio Sapienza Sr. (1755–1829) had emigrated from Naples to Russia in 1783 and served as a musician and voice teacher at the Russian imperial court.
)[1] At the age of 28, Sapienza left Russia for Naples to continue his musical studies at the conservatory there with Giacomo Tritto, Niccolò Antonio Zingarelli and Pietro Generali, during which time he composed two Masses, several motets and a Salve regina.
According to the Allgemeine musikalische Zeitung, he was also one of the several composers who produced the dramatic cantata, La fondazione di Partenope, performed at the Teatro San Carlo on 12 January 1824 to celebrate the birthday of King Ferdinand I of the Two Sicilies.
[2] Sapienza returned to St. Petersburg in 1828 where he served as choirmaster and conductor at the Imperial Theatre until his death in 1855.