[7] Senzatela had a 3–1 win–loss record and a 2.81 ERA in five starts in April, and was named the National League's Rookie of the Month.

[10] In 2021, he set career highs in starts (28), innings pitched (156+2⁄3) and strikeouts (105), despite posting a record of 4–10 with a 4.42 ERA.

Following the season, the Rockies signed Senzatela to a five-year contract extension worth $50.5 million.

In the start, he allowed one run on a Brandon Nimmo solo shot, which ended being the decider in a 1–0 loss.

[14] In his next start on May 10, Senzatela went 2+2⁄3 innings and allowed three runs on four hits, including a two–run homer off the bat of Andrew McCutchen.

[18][19] On July 14, it was announced that Senzatela would undergo Tommy John surgery and miss the remainder of the season.

[21] Senzatela made his season debut on September 16, 2024 allowing four hits , two earned runs and two strikeouts in three innings.