The Cardinals' fourth-round selection of the 2014 MLB draft, Gomber attended Florida Atlantic University and played college baseball for the Owls.

Austin Gomber attended West Orange High School in Winter Garden, Florida,[1] and, after graduation, made himself available for the Major League Baseball (MLB) draft, but remained unselected.

There, he played three seasons, made 41 starts and registered a 3.27 earned run average (ERA) in 244+2⁄3 innings pitched (IP).

In his second start for Springfield on July 30, 2016, he pitched seven innings against the Northwest Arkansas Naturals and allowed one hit, no runs, two walks and struck out three.

[10] After the season, the Cardinals assigned Gomber to the Glendale Desert Dogs of the Arizona Fall League (AFL).

He finished the 2017 season 10–7 with a 3.34 ERA and 1.17 WHIP in 26 starts, as he pitched 143 innings (4th in the Texas League) and had 140 strikeouts (2nd) and gave up 61 walks (5th) and 17 home runs (6th).

He was recalled once again on May 31,[16] and he made his major league debut on June 2, pitching three scoreless innings of relief against the Pittsburgh Pirates at Busch Stadium in a 3–2 walk-off win.

[20] On February 1, 2021, Gomber was traded to the Colorado Rockies alongside minor league players Elehuris Montero, Mateo Gil, Tony Locey and Jake Sommers in exchange for Nolan Arenado.

[25] In 2024 Gomber started 30 games and posted a 5-12 record and a 4.75 ERA with 116 strikeouts in 165.0 innings and allowed the most home runs in the National League that year.