Seripando was the eldest son of Giovanni Ferdinando and Isabella Luisa Galeota, minor nobility living in the Porta Capuana district of Naples.
In September 1506, when Troiano tried to join the Dominicans of Santa Caterina a Formiello, Antonio brought him back.
In March 1507, however, he approved his entrance into the Augustinian friars of San Giovanni a Carbonara, which was more congruent with Antonio's intellectual interests.
[3] In 1512, Seripando joined the entourage of Cardinal Luigi d'Aragona as a secretary and lived in Rome.
Following the cardinal's death in January 1519, he returned to Naples, but intellectual pursuits brought him back to Rome in March 1521.