It has been translated and published in many countries, including in Sweden, Egypt and Norway, and is one of Karchkhadze's most popular works in Georgia.

Antonio and David is a strained drama, which describes a struggle of soul, on the background of religious and historical discourse.

In 1600 AD, in a remote Italian city, a young peddler named Bartolomeo d'Aniti is called to the court and ordered to accompany a delegation to the distant land of Georgia, which is referred to as Colchis in the novel.

Antonio thought that by accepting the pardon, he betrayed his ideals and spiritual brethren and after all these years, he couldn't forgive himself for his decision.

After a long journey, they reach the bank of Samegrelo, where they were sheltered by its Prince, hardy yet very friendly man who got acquainted with Bartolomeo rather quickly.

The baby was named David and was sold in Istanbul, but he got free very soon and returned to his motherland, assembling a group of robbers and proceeded to terrorise the countryside.

At night, David visited Antonio and Bartolomeo and revealed that he disbanded his group, but didn't know what to do next to atone for his past.

Nobleman of village and the corrupt priest reported them to the Prince (alongside numerous false accusations against Antonio and Bartolomeo) who sent his retinue (which included people from the mission) at traveler's place and asked them to return to the capital.

Sorrowful and enraged upon hearing death of Antonio, David left for a while and met Bartolomeo after few days.

He told Bartolomeo that he captured the cowardly noblemen and the corrupt priest who slandered Antonio in front of the court and sold them, instead redeeming young mother and her little child.

The author uses a narration style that incorporates Georgian ways of life from a foreigner's point of view.

The novel is presented against a backdrop of snow-capped mountains, lush valleys, dense forests, the Black Sea, slave traders, bandits, bounty hunters, noble princes, priests and "false counts.

"[2] In 2014, Ministry of Culture and Monument Protection of Georgia supported Jemal Karchkhadze's novel "Antonio and David", to be translated into Arabian.