His grandfather Francesco Giamberti was a woodworker, and his uncles Giuliano and Antonio da Sangallo were noted architects of the time.
Despite his family ties, Cordiani spent his early life in poverty, resulting from the political and religious turmoil of the fifteenth century.
[1] At around age twenty, in 1503, young Cordiani followed his uncles to Rome in order to pursue a career in architecture;[2] he ended up taking the name ″Sangallo″ and then becomes known as Antonio da Sangallo (the younger).
[3] Due to his success, Sangallo was eventually put in charge of the Passetto di Borgo between the Papal apartments and the Castel Sant'Angelo.
Although Leo X's papacy enabled Sangallo to connect with great artists, his main encouragement came from Cardinal Alessandro Farnese (later Pope Paul III).
[1] Through these projects, Sangallo acquired the reputation of a master architect in the city of Rome, mostly due to his originality and personal style.
While he was working with Raphael on Saint Peter's Basilica, Sangallo had to compromise, but also search to find his own architectural style.
After the year 1530, more people joined his group, which included Bartolomeo Baronimo and Giovan Francesco’s brother Sebastiano also known as Aristotile.
[7] Antonio da Sangallo incorporated mathematics into his design and preferred using the orthogonal mode of representation instead of making section and perspective drawings.
[7] The fifth stage consisted of making wooden presentation models and detailed drawings for spaces such as atriums, stairwells, and windows of the building.
[7] Sangallo was eventually hired to build the foundation for the church of San Giovanni dei Fiorentini on the bank of the Tiber.
[10] Sangallo was also hired to do similar work on the Vatican loggias, which had shown signs of weakness due to poor construction; his reinforcements stand today.
Sangallo was also a noted military architect, working on the fortifications of numerous cities such as Parma, Piacenza, Ancona and Orvieto.
In Orvieto, he was also tasked by Pope Clement VII with building a well, called Saint Patrick's Well, noted as a marvel of engineering.
[7] Sangallo was also a noted military architect, working on the fortifications of numerous cities such as Parma, Piacenza, Ancona and Orvieto.
[11] [previous sentence not changed but added citation] One of the most significant projects for Antonio’s career was to design and build the Fortezza da Basso in 1534.
Sangallo the Younger almost completed the project in two years for the new Imperial Duke of Florence, Alessandro de' Medici.
[7] Military construction was a different type of architecture that required strong fortifications and a vast labor force to excavate ditches and transport the materials.
[7] The fortifications that Sangallo designed were built to resist the cannonballs and explosive mines that could negatively impact the structural integrity of the building.
[13] It was after the sack of Rome that Antonio da Sangallo was responsible for its undertaking, with construction of the Basilica beginning in April 1506.