Returning to Urbino, he was employed by Duke Guidobaldo da Montefeltro in the decorations of his palace, and showed extraordinary aptitude for theatrical adornments.

[citation needed] From Urbino, he travelled to Rome and painted one of his masterpieces, The Resurrection, for the church of Santa Caterina da Siena.

[1] Francesco Maria I della Rovere, duke of Urbino, recalled Genga, and commissioned him to execute works in connection with his marriage to Eleonora Gonzaga in 1522.

Its sunken court is the direct precedent for the more famous one at Villa Giulia, Rome,[3] For the fresco decoration of the interior, Genga recruited a number of major Mannerist painters, including Francesco Menzocchi, Bronzino, Dosso Dossi, and Raffaellino dal Colle.

One of his leading works is in the church of Sant'Agostino in Cesena: a triptych in oil, representing the Annunciation, God the Father in Glory, and the Madonna and Child.