In 1496, Antonio de Rojas Manrique was selected by the King of Spain and confirmed by Pope Alexander VI as Bishop of Mallorca.

[5][6][7][8] He was one of the three ambassadors to England that left on 26 August 1501 to accompany princess Catherine of Aragon on her marriage to Arthur, Prince of Wales.

[4][7] In 1524, he was appointed by Pope Clement VII as Bishop of Palencia and the first Patriarch of the West Indies.

[1][3][7] On 3 July 1525, he was appointed by Pope Clement VII as Bishop of Burgos.

[2][7] He served as Bishop of Burgos and Patriarch of West Indies until his death on 27 June 1527.