Born into a noble family from Zakynthos, he went on to serve as President of the Ionian Senate and Prince (head of state) of the Septinsular Republic starting from 1803 until the second French rule of the Ionian Islands in 1807.

Antonios was born in 1748 in the Venetian-ruled Ionian island of Zakynthos (or Zante).

He was a member of the noble Komoutos family which had a long history on the island.

Tradition holds that early members of the family had settled in Zakynthos during the 15th century, following the fall of Constantinople and after they first sought refuge in Methoni and around the Peloponnese.

[1] Spyridon Georgios Theotokis, president of the Senate and governor of the Septinsular Republic, died on 24 November 1803 and Antonios Komoutos was elected as the new president of the Senate and head of state "Prince".