He was signed by the San Diego Chargers as an undrafted free agent in 2007.

He was also a member of the San Francisco 49ers, Carolina Panthers, and Miami Dolphins.

Applewhite was signed as an undrafted free agent on April 30, 2007 by the National Football League's San Diego Chargers.

Applewhite was waived during final cuts in 2008 but was re-signed to the team's practice squad.

One game into the season on September 9, he was signed to the active roster after linebacker Shawne Merriman was placed on injured reserve.