Founded in 1967, the school hosts approximately 400 students and 90 staff members from at least 35 countries.

Since September 1991, students at AIS have had access to specialised facilities for art, music and theatre.

[citation needed] As of 2021, AIS has completed construction of its new STEM facilities, which encompasses the renovation of what used to be called the "Old Gym" - the former gymnasium.

[citation needed] AIS is a member of the Northwest European Council of International Schools (NECIS), playing competitively against other schools in Northwestern Europe: Denmark, Germany, Luxembourg, the Netherlands, Norway and Sweden.

The AIS sports teams are named after the Griffin, a mythical creature with the body of a lion (symbolising the Flemish community) and the head and wings of an American eagle (a nod to the school's roots as the American School of Antwerp).