The company began by publishing original limited series and graphic novels, many with mature themes; it later pivoted and became known for its family-friendly titles as well as cross-media properties such as comics based on video games.

Notable creators associated with Ape Entertainment included Neil Druckmann, Francesco Francavilla, Chandra Free, Jonathon Dalton, Joe Staton, Geoffrey Thorne, Josh Wagner, and Rob Worley.

Ape Entertainment was founded in 2003 by Brent E. Erwin, with a background in film production, and David Hedgecock, with experience in comic book retail and editing.

1 and 2, the 2-issue series A Different Pace, the Atomic Age Treasury of Pulp Action by David Wharton, and Make Your Own Comics: The Small Press Primer by Mike Hall.

That summer, Ape Entertainment editor-in-chief Brent E. Erwin, who had a background in retailing, acquired two locations of Buddy Saunders' Lone Star Comics chain.