Due to the new format of the CONCACAF Champions League, Mexican clubs do not begin their participation until February, thus the teams qualified to 2018–19 CONCACAF Champions League (Monterrey, Santos Laguna, Toluca, UANL) will participate in this season's Copa MX.
The draw for the tournament took place on 5 June 2018 at the Iberostar Hotel in Cancún, Mexico.
[29] Clubs in Pot 1 were drawn to be the seed of each group according to the order of their drawing.
[28] The champions of the last two editions, Monterrey (who is also first in Aggregate table) and Necaxa are also in Pot 1.
[28] Pot 3 contained Liga MX clubs who ended 10–18 (excluding Lobos BUAP) in the Aggregate table.