Apizaco is a city in Apizaco Municipality located near the geographic center of the Mexican state of Tlaxcala, approximately 25 minutes by car from the state's capital city of Tlaxcala.

Those seeking to reach the port of Veracruz by railroad from Mexico City must travel through Apizaco.

It is of major commercial and trade value to the state because it is halfway on the road between Mexico City and the port of Veracruz.

The census of 2005 reported a population of 49,459 in the city of Apizaco, while the municipality had 73,097 inhabitants.

The municipality has an area of 56.83 km² (21.94 sq mi) and includes a small number of other communities, the largest of which are Santa Anita Huiloac, Santa María Texcalac, and San Luis Apizaquito.