Apostol Arsache (in Romanian) or Apostolos Arsakis (Greek: Απόστολος Αρσάκης; 1789 – 1869) was a Greek-Romanian politician and philanthropist.

[3] Arsache was born in the village of Hotovë, Përmet District, modern southern Albania, then in Ottoman Empire.

[7][8][9] In 1800, Arsache moved together with his family to Vienna, there he was educated in a school of the local Greek diaspora.

At 1807 Doukas published an epigram composed by Arsache about the work, Breviarium historiae Romanae, of historian Eutropius.

In 1850 he offered large sums of money for the establishment of a female educational institutions in the Greek capital, Athens, housed in a luxurious mansions at the city center.