The Roman Catholic Archdiocese of Mary Most Holy in Astana (Latin: Archidioecesis Sanctae Mariae in Astanansis) is a Latin Church archdiocese of the Catholic Church in Kazakhstan.

The founding and only apostolic administrator, Tomasz Peta, was appointed the first Archbishop of Mary Most Holy in Astana by John Paul II on May 17, 1999.

Pope John Paul II erected it as the Apostolic Administration of Astana on July 7, 1999, on territory split off from the then Apostolic Administration of Kazakhstan (which lost more territories and became the diocese of Karaganda and soon after, unusually, daughter diocese Astana's suffragan), and visited it in September 2001.

Its ecclesiastical province comprises the metropolitan's own archdiocese and the following suffragan jurisdictions : (all Roman Rite, so far European Latin missionaries)

This article on a Roman Catholic diocese in Asia is a stub.