It is a diplomatic post of the Holy See, whose representative is called the Apostolic Nuncio with the rank of an ambassador.
The title Apostolic Nuncio to Malawi is held by the prelate appointed Apostolic Nuncio to Zambia; he resides in Zambia.
The Holy See represented its interests in the region through its Delegation to East Africa until, with the decolonization of Africa in the mid-20th century, it established relationships with the new independent countries of that continent.
Malawi, which under the name Nyasaland had been a protectorate of the United Kingdom, became an independent nation in 1964.
The Holy See established its Nunciature to Malawi and named its chief on 21 May 1966.