The Apostolic Prefecture of Kampong Cham is a territorial subdivision of the Roman Catholic Church in Cambodia.

The prefecture covers an area of 66,347 km2 of eastern Cambodia, covering the provinces of Kampong Cham, Kratié, Stung Treng, Ratanakiri, Mondulkiri, Svay Rieng, Tboung Khmum and Prey Veng.

The prefecture is subdivided into 24 parishes, and has 13 priests altogether.

The prefecture was erected on September 26, 1968, when the Apostolic Vicariate of Phnom Penh (which was until then responsible for all of Cambodia) was split into three parts.

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