The Apostolic Vicariate of Iquitos (Latin: Vicariatus Apostolicus Iquitosensis), originally Apostolic Prefecture of San León del Amazonas, is a Latin Church pre-diocesan missionary jurisdiction apostolic vicariate of the Catholic Church in Amazonian northern Peru.

It is immediately exempt to the Holy See and not part of any ecclesiastical province.

Its cathedral, the Catedral San Juan Bautista (St. John the Baptist), is in the episcopal see of Iquitos.

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