The Apostolic Vicariate of Leticia (Latin: Apostolicus Vicariatus Laetitiae) in the Catholic Church is located in the city of Leticia, Amazonas, in Colombia.

On 8 February 1951 Pope Pius XII established the Prefecture Apostolic of Leticia from the Vicariate Apostolic of Caquetá.

Blessed John Paul II elevated it to a Vicariate Apostolic on 23 October 2000.

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