The Diocese of Ipiales (Latin: Ipialensis) is a Latin Church ecclesiastical territory or diocese of the Catholic Church in Southern Colombia.

It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of Popayán.

As per 2015, it pastorally served 560,288 Catholics (90.2% of 620,969 total) on 11,089 km2 in 45 parishes and 2 missions with 95 priests (87 diocesan, 8 religious), 2 deacons, 86 lay religious (16 brothers, 70 sisters) and 37 seminarians.

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