Appenweier (Low Alemannic: Appewiir) is a municipality in western Baden-Württemberg, Germany in the district of Ortenau.

Appenweier consists of the main municipal Appenweier (4,075 inhabitants), Urloffen (4,301 inhabitants), known for horseradish-growing, and Nesselried (1,383 inhabitants).

The Nesselried district runs through the Wannenbach valley, while Urloffen lies north of Appenweier.

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