Appleton is an unincorporated community and census-designated place (CDP) in Griffin Township, Pope County, Arkansas, United States.

It was first listed as a CDP in the 2020 census with a population of 399.

[2] The town contained a post office from 1879 until 1968.

[3] It was named for an apple orchard that surrounded an early drug store.

[4] It is in the Hector School District.