Appleton is a town in Knox County, Maine, United States.

The plantation and town was named for Nathaniel Appleton, who was for more than 20 years an officer of the Twenty Associates, the proprietors of Appleton, as well as Camden, Hope, Liberty, and Montville.

There were 646 housing units at an average density of 19.7 per square mile (7.6/km2).

27.2% of all households were made up of individuals, and 9% had someone living alone who was 65 years of age or older.

There were 547 housing units at an average density of 16.7 per square mile (6.4/km2).

21.7% of all households were made up of individuals, and 7.5% had someone living alone who was 65 years of age or older.