[1] Appointment with Adventure presented stories whose settings varied among locations in the United States and in places in the world beyond U.S. borders.
Guest stars who appeared in episodes included Jack Lord, Patricia Breslin, Jack Klugman, Barbara Britton, Edie Adams, James Daly, Neville Brand, Viveca Lindfors, Theodore Bikel, Kim Hunter,[3] Polly Bergen, Betsy Palmer, Gena Rowlands, Phyllis Kirk, Dane Clark, Tony Randall, Gene Barry, and Paul Newman.
The trade publication Variety called the first episode a "clinker" and noted the difficulty of doing an outdoor-set adventure show live.
[11] The story received mixed comments, with the adventure elements praised, while treatment of a romantic triangle was called "a trite and familiar formula.
[11] The review concluded added that executives would have to decide "whether they want to do a real adventure series or a soap opera with an outdoor setting.