She was a grand-niece of the emperor Augustus as her father was the son of Octavia Major.
[1] For a long time it was uncertain how exactly she was related to Augustus, with many assuming she was a daughter of Claudia Marcella Major but historian Ronald Syme reports that an inscription from Asia confirms she was the daughter of that consul of 29 BC Sextus Appuleius and a sister of Publius Quinctilius Varus.
In 17, she was charged by Tiberius with adultery and insulting the Roman empress (his mother Livia) and his step-father Augustus.
She was exiled from Rome and ordered not to come within 200 miles of the city.
Manlius, her lover, was banned from Italy and Africa Province.