Called the Tuono R Limited and in hindsight being a proof of concept for the future RSV Tuono Factory, it had the 94.9 kW (129.0 PS; 127.3 hp) engine of the RSV Mille R, a gold colored frame and was built solely out of high end materials such as carbon fiber, kevlar and titanium.

The reason for this is to avoid potential speed wobble under full acceleration due to the motocross style handlebars atop high machined ergal risers causing the rider to sit more upright, resulting in less weight over the front wheel.

The Tuono base models feature an adjustable Sachs rear shock absorber and Showa front suspension.

It sports dual overhead cams, double balance shafts, 4 valves per cylinder, electronic fuel injection, twin spark ignition and the same two-into-one exhaust as used on the RSV Mille.

The RSV Tuono Factory is a high spec model based upon the Aprilia RSV Mille R. Compared to the standard RSV Tuono it has forged alloy wheels, gold anodized Öhlins Racing front forks, fully adjustable Öhlins Racing rear monoshock, a fully adjustable Öhlins Racing steering damper, radially mounted Brembo brake calipers and it extensively uses carbon fiber parts for weight reduction.

The exhausts are also lighter the Tuono is equipped with titanium Akrapovic sports mufflers with stainless steel manifolds.

However, since the parts between the two are interchangeable and abundant this should not hinder anyone wanting to use the Tuono as a track bike from changing the rear shock.

The BRP-Rotax V990 60° V-Twin engine was upgraded significantly when compared to the first generation Tuono: different gear ratios (close ratio with longer first gear), larger throttle bodies, single spark plug, minor cosmetic changes and an increase in power output to 99.8 kW (135.7 PS; 133.8 hp) @ 9500 rpm.

The Tuono 1000 R Factory comes with fully adjustable Öhlins Racing rear mono-shock and front forks, blue- or gold-anodized (depending on model year) forged aluminum wheels, a frame finished in gold, a paint job sporting the signature Aprilia Lion's head on the fuel tank and the extensive use of carbon fiber parts.

The use of forged aluminum wheels and carbon fiber explains the weight difference of 4 kg (9 lb) between the two versions in favor of the Factory model.

For the 2014 model year, various refinements including a larger 18.5 L fuel tank, more comfortable saddle, and 3 position race ABS brakes were introduced.

Now called the Aprilia Tuono V4 1100 RR and Öhlins-equipped Factory model with a claimed 175 hp (130 kW) @ 11,000 rpm and a wet weight of 472 lb (214 kg).