On 15 August 2010, Aprilia became the most successful motorcycle racing brand in history, surpassing fellow Italian MV Agusta with a record 276th victory.

[2] Aprilia began campaigning in the 500cc class in 1994 with a 250 V twin motor enlarged to 380cc in hopes of using its lighter weight and nimble handling as an advantage against the heavier, V4 engine bikes used by the competition.

[3] The bike eventually displaced 430cc and had its best result with a third place by rider Doriano Romboni at the 1997 Dutch TT but, could never overcome power disadvantage during the starting line sprint and was withdrawn at the end of the 1997 season for further development.

[9] In 2025, defending riders' champion Jorge Martín signed for the factory team[10] from Pramac Racing replacing the retiring Aleix Espargaró.

Aprilia made their international racing debut in the Motocross World Championship competing in the 125cc class from 1976 until 1981 with a best result being a fifth place in the 1979 season with rider Corrado Maddi.

On August 30, 1987, at San Marino Grand Prix in Misano, Loris Reggiani won the first World Speed Championship with an AF1.

For example, they progressed with development of a V-2 500 cc Grand Prix bike when other teams were moving to V-4 configurations for what some believed was better and more usable power outputs.