Aravaipa Creek originates on the southeast flank of the Galiuro Mountains at Durkee Canyon and Blue Peak at 8,889 feet (2,709 m).

On the west side of the valley, the creek follows the northeast and north perimeter of the Galiuro Mountains massif flowing northwest, west, and then southwest through and around the range's north end to meet the San Pedro River a few miles south of Dudleyville.

There is also access to Klondyke via Arizona State Route 266 to Bonita (passing near Fort Grant) and thence on a gravel road north through the valley.

West of Klondyke in the Galiuro Mountains is the location of the well known Power's Cabin shootout.

The creek goes northwest then southwest through the canyon and downstream about 9 miles (14 km) to meet the San Pedro River and Arizona State Route 77 between Dudleyville and Mammoth.