He is the brother of Bollywood actor Salman Khan—with whom he attended the Scindia School, Gwalior—and actor-producer Sohail Khan.

He has starred in many multi-starrer hit films such as Pyaar Kiya To Darna Kya (1998), for which he received a Filmfare Award for Best Supporting Actor nomination, and Garv: Pride and Honour (2004), where he acted opposite his brother Salman.

He played a villainous role in the 2003 film Qayamat: City Under Threat, which was successful at the box office.

[citation needed] He also played supporting roles in director Priyadarshan's comedy films Hulchul (2004), Malamaal Weekly (2006) and Bhagam Bhag (2006).

He played supporting roles as a police officer (Constable Javed Shaikh) and a mobster (Moscow Chikna) in the 2007 multi-starrers Shootout at Lokhandwala and Fool and Final respectively.

He also made a cameo, alongside his brother Sohail Khan, in the blockbuster Jaane Tu...

His former wife Malaika Arora Khan was featured in the popular item number "Munni Badnaam".

[7] On 12 March 2011, while Khan was a special guest of Australia's Indian film festival, Bollywood & Beyond, he helped his former wife Malaika Arora lead a successful world record attempt in Melbourne.

[22] In 2018, Arbaaz Khan confessed to having placed bets on Indian Premier League matches (IPL) in the previous five years.

[23] According to a police official, the Bollywood actor admitted that he had been betting on cricket matches for the past five to six years.