[citation needed] He was involved primarily in action films throughout the 1990s, playing the male protagonist in most of the movies he acted in during the decade.

[clarification needed] He starred opposite Isha Koppikar in Arjun Rampal's debut movie Pyaar Ishq Aur Mohabbat (2001).

[9] He played negative roles in movies such as Khel – No Ordinary Game (2003), Baaz: A Bird in Danger (2003), Main Hoon Na (2004), Rudraksh (2004), Cash, No Problem (2010), and A Gentleman (2017).

[11] In 2009, Shetty bagged South Asian International Film Festival's Best Actor Award for his role in Naxalites based Indian movie Red Alert.

He produced films such as Khel – No Ordinary Game (2003), Rakht (2004) and Bhagam Bhag (2006) under the banner of Popcorn Motion Pictures.

[18] In 2023, Shetty portrayed ACP Vikram Chauhan in Hunter Tootega Nahi Todega, an action thriller web series that follows his character's journey into the dark alleys of Mumbai's crime world.

Its founder Jitendra Chouksey launched Fittr in January 2016 as a community on Facebook to address the challenges in the fitness industry.

[20] Shetty has appeared as a host for India's leading fitness reality shows Biggest Loser Jeetega on Sahara One.

Suniel Shetty was participant in the Hiru Golden Film Awards 2014 and 2016 in Sri Lanka as a special guest.

He is an advisor for Vipla Foundation, an NGO that works towards empowering underprivileged communities through education, skill development, and social welfare initiatives to create sustainable and inclusive growth.