The building was designed by the local architect Edward H. Glidden and is located on a 33-acre (130,000 m2) campus on the northeast edge of the City of Baltimore.

During that year, a smaller wing was added onto the building to house the instrumental music department facilities, including a concert practice room.

As E. Patrick Maloney, Richard "Coach" Patry, and Albert E. Frank left the school, a new trend was beginning to emerge.

At the start of the 21st century, with the endowment secured, the campus grounds were revamped with new fencing, a concession stand and a new bowl stadium with terraced seating.

The friary was reconstructed to better reflect the number of religious living on the grounds and the balance of the space provided room for the relocation of the Lawrence Cardinal Shehan Library to the second floor, adjacent to the academic wing of the building.

A grant provided funds for a rehabilitation of the auditorium seating and, in summer 2005, further renovations funded by a capital campaign provided a new faculty dining room, a relocated bookstore, conference rooms and offices for the development director, athletic director and alumni association.

Under the theme "In Giving We Receive" an aggressive capital campaign was launched in 2008 to generate funds for improvements to the campus in advance of the school's 50th anniversary in 2011.

In summer 2008, a second parking lot was added and the interior roads were renovated, reestablishing the Auditorium lobby as the main entrance of the school.

The center is named for Gerard E. Holthaus '67, then-CEO of Algeco Scotsman International, who made a $1 million leadership gift to the building campaign.

The new facility, completed in May 2010, houses choral and instrumental music practice rooms, as well as storage for Blackfriars' Theatre and space for the Visual Arts Department.

His successor, nominated by the school board and the friars and confirmed by Archbishop Edwin O'Brien, was Fr.

With additional changes in both assistant principal offices and campus ministry, 2011–2012 had the largest leadership transition in the school's history.

In spring 2021, principal Brian Kohler announced that he would be accepting a position as President of Archbishop Spalding High School.

After an extensive search, executive director of enrollment & marketing Mr. Jeremy Joseph (‘96) was named as the next principal of Archbishop Curley High School.

These students achieve baccalaureate honors through a Capstone project as well as numerous Advanced Placement courses and electives.

The college-preparatory curriculum offers development in 21st century skills for students performing at or near grade-level ability.

Intramural sports provide students an opportunity for informal recreation and competitive play throughout the school year.

Curley's Franciscan Youth Ministry program offers students opportunities for prayer, liturgy and fellowship, as well as a commitment to service, social justice and community outreach.

Archbishop Curley High School was a founding member of the Maryland Interscholastic Athletic Association (MIAA).

The principal still functions in the role of daily school management and as chief academic officer, reporting to the president.