Elizabeth Seton High School was established on March 15, 1957, and opened with an enrollment of 138 freshmen and a faculty of six Daughters of Charity in September 1959.

As early as 1965, the Maryland State Department of Education issued a Certificate of Approval to the school and in 1968 the Middle States Association of Colleges and Secondary Schools accredited it.

Elizabeth Seton was named one of 10 private schools of distinction by The Washington Post in 2005.

[4] Seton covers grades 9–12 and can hold about 650 students.

[5] The school was named in honor of the American Catholic saint Elizabeth Ann Seton.