[2][6] In 1891 the Holy Trinity Greek Orthodox parish's first home was in part of an Evangelical church on West 53rd Street for US$50 per month ($1,700 in current dollar terms).

[1][3] On September 18, 1999, Archbishop Demetrios was enthroned at the cathedral as primate of the Greek Orthodox Church in America.

Robert Stephanopoulos, had been demoted and relieved of responsibilities at the cathedral in January 1999 by Archbishop Spyridon of America, but by late 1999 had regained his position.

[12][13] In 2001 television journalist and former political advisor George Stephanopoulos and comedian Alexandra Wentworth were married there.

[16] The interior has Byzantine mosaics, botticino marble for the walls, columns, and altar, and imported Italian stained glass.