Marie Anne of Austria (Maria Anna Franziska Theresia Josepha Medarde; 8 June 1804 – 28 December 1858) was an Archduchess of Austria as the daughter of Franz II, Holy Roman Emperor and his second wife, Maria Theresa of Naples and Sicily.

She never married or had any children due to her being intellectually disabled with a severe facial deformity and having to spend the rest of her life in Hetzendorf Palace.

She was the tenth child born to her parents, the Holy Roman Emperor Francis II by his second wife, Princess Maria Theresa of Naples and Sicily.

She is said to have been intellectually disabled (like her eldest brother, Emperor Ferdinand I) and to have a severe facial deformity.

[1] probably linked to the genetic inbreeding within her family; her parents were double first cousins.